Dr Warren Joubert - Clinical Trials

Clinical trial involvement: Principal investigator:

CO20: A Phase III randomized Study if Brivanib Alaninate (BMS-582664) in combination with Cetuximab in patients with K-RAS wild type tumours previously treated with combination chemotherapy for metastatic colorectal cancer

GAP: Phase II study of Gemcitabine and nab-Paclitaxel for Resectable Pancreatic Cancer

MEK113478: A Randomized, Double-Blind Placebo-Controlled Phase II Study of the MEK inhibitor GSK1120212 plus Gemcitabine vs. Placebo plus Gemcitabine in Subjects with Metastatic Pancreatic Cancer

SCOT Study: Short Course Oncology Therapy. A phase III, randomised, multi-centre study of adjuvant chemotherapy in colorectal cancer.

ICECREAM: Randomised Phase II study of cetuximab alone or in combination with irinotecan in patients with metastatic CRC with either KRAS WT or G13D mutation.

PALETTE: A randomized double blind phase III trial of Pazopanib versus placebo in patients with soft tissue sarcoma whose disease has progressed during or following prior therapy.

LDE 225: A stratified multi-arm Phase 2 study evaluating the efficacy and safety of LDE225 in patients with advanced/metastatic sarcomas

YONDELIS: A Randomized Controlled Study of YONDELIS (Trabectedin) or Dacarbazine for the Treatment of Advanced Liposarcoma or Leiomyosarcoma Previously Treated With an Anthracycline and Ifosfamide

CASPS: A Phase II Trial of Cediranib in the Treatment of Patients with Alveolar Soft Part Sarcoma

DENOSUMAB: in giant cell tumour of bone

PICASSO-III: Palifosfamide in first line treatment of metastatic soft tissue sarcomas

ERIBULIN: in advanced soft tissue L- sarcomas

TRABECTEDIN in advanced soft tissue L-sarcomas

MORAb-004: advanced soft tissue sarcomas

Olaratumab in soft tissue sarcoma: phase 3 trial

Epizyme/ Tazemetostat trial in rare sarcoma subsets

Enliven/ PLX 108-10 A Double-blind, Randomised, Placebo-controlled Phase 3 Study of Orally Administered PLX3397 in subjects with pigmented Villonodular Synovitis or Giant Cell Tumor of the Tendon Sheath

Javelin gastric cancer trial: phase 3 trial with Avelumab maintenance therapy in first line metastatic gastric or GOJ adenocarcinoma

INCAGN 1876-201 trial. Phase I combination immunotherapy in multiple cancer types

ACTICCA-1 Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma

EZH-202 A Phase II Multicentre study of the EZH2 inhibitor Tazemetostat in adult subjects with INI1-Negative tumours or relapsed/refractory synovial Sarcoma

UGI NABNEC A randomised phase II study of nab-paclitaxel in combination with Carboplatin as first line treatment of Gastrointestinal Neuroendocrine Carcinoma.

rEECur International Randomised Controlled Trial of chemotherapy for the treatment of recurrent and primary refractory Ewing Sarcoma

MONARCC A randomised phase II study of Panitmumab monotherapy and panitumumab plus 5 fluorouracil as first line therapy for RAS and BRAF wild type metastatic colorectal cancer

EZH – 501 Tazemetostat Rollover Study (TruST): An Open-Label, Rollover Study

UGI DCC- 2618-03-002 A phase III Interventional, randomised, multicenter, open-labelstudy of DCC-2618 vs Sunitinib in patients with advanced GastrointestinalStromal Tumours after treatment with Imatinib.

Sub- investigator:

SAVE-ONCO: Evaluation of AVE5026 in the Prevention of Venous Thromboembolism in Cancer Patients Undergoing Chemotherapy

LAP-07: Randomised multicenter phase III study in patients with locally advanced adenocarcinoma of the pancreas: gemcitabine with or without chemoradiotherapy and with or without erlotinib.

AVAglio-BO20910: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme.

RAISE: Ramucirumab Plus FOLFIRI Improved Survival in Metastatic Colorectal Cancer following Progression on a Bevacizumab-Based Regimen

ATTACHE: A Trial in the Timing of Surgery and Adjuvant Chemotherapy for Hepatic Metastases from Colorectal Cancer

ALTTO- ANZ072/BIG2-06: A randomised, multi-centre, open-label, phase III study of adjuvant lapatinib, trastuzumab, their sequence and their combination in patients with HER2/ErbB2 positive primary breast cancer

SOFT-IBCSG 24-02: A phase III trial evaluating the role of ovarian function suppression and the role of exemestane as adjuvant therapies for premenopausal women with endocrine responsive breast cancer

CHALLENGE: A Phase III study on the impact of physical activity program on Disease-Free Survival in patients with High risk Stage II or Stage III Colon Cancer: A Randomized Controlled trial.

DOCTOR: A Randomised Phase II Trial of Pre-operative Cisplatin, 5 Fluorouracil and Docetaxel or Cisplatin, 5 Fluorouracil, Docetaxel plus Radiotherapy based on poor early response to standard chemotherapy for resectable adenocarcinoma of the oesophagus and/or OG Junction.

FOXFIRE: Assessment of Overall Survival of FOLFOX6m plus SIR-Spheres microspheres versus FOLFOX6m alone as first-line treatment in patients with non-resectable liver metastases from primary colorectal carcinoma in a randomised clinical study

TOPGEAR: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer

CO23: A Phase III Randomized Study of BBI608 and Best Supportive Care versus placebo and Best Supportive Care in patients with pre-treated advanced colorectal cancer.

APEC: An Asia Pacific non-randomized, open-label phase II study evaluating the safety and efficacy of FOLFIRI plus cetuximab (Erbitux) or FOLFOX plus cetuximab as first-line therapy in subjects with KRAS wild-type metastatic Colorectal cancer (APEC-Study)

PETACC6: Preoperative chemoradiotherapy and postoperative chemotherapy with capecitabine and oxaliplatin vs. capecitabine alone in locally advanced rectal cancer

QUASAR2: Multicentre international study of Capecitabine+/- Bevacizumab as adjuvant treatment of colorectal cancer.

EVERSUN: A phase 2 trial of Everolimus alternating with Sunitinib as first line therapy for advanced renal cell carcinoma

ACCLERATED BEP: A feasibility study of accelerated BEP as first line chemotherapy for advanced germ cell tumours

REGISTER:A Multicentre Phase II study of Risk Evaluation in GIST with Selective Therapy Escalation for Response

AYA PK: Pharmacokinetics and Pharmacodynamics of Doxorubicin in Children, Adolescents and young adults with Newly Diagnosed Osteosarcoma, Ewing Family of Tumours and Hodgkin Lymphoma

TROG 09.03: A Phase II Efficacy Study of Chemo-radiotherapy in PET Stage II and III Merkel Cell Carcinoma of the Skin

EMR 100070-008 (Javelin) trial: Avelumab therapy in 3rd line gastric cancer

BGB A317 -001 phase 1 trial with experimental anti- PD-1 monoclonal antibody BGB- A317 in subjects with advanced tumours

PUBLICATIONS:

Activity of cediranib in alveolar soft part sarcoma (ASPS) confirmed by CASPS (cediranib in ASPS), an international, randomised phase II trial (C2130/A12118).
Ian Robert Judson, James P Morden, Michael Gordon Leahy, Vivek Bhadri, Quentin Campbell-Hewson, Ricardo Cubedo, Adam Dangoor, Ivo M. Hennig, Warren Lance Joubert, Sarah Kernaghan, Antonio Lopez-Pousa, Beatrice M. Seddon, Claire Snowdon, Martin Tatersall, Christy Toms, Javier Martinez-Trufero, Judith Bliss
Lancet Oncol. 2019 Jul;20(7):1023-1034

A multicenter, phase II trial of preoperative gemcitabine and nab-paclitaxel for resectable pancreas cancer: The AGITG GAP study.
Andrew Barbour , Nicholas O’Rourke , Manju D. Chandrasegaram , Yu Jo Chua , James Kench , Jaswinder S. Samra , Nick Pavlakis , Koroush S Haghighi , Sonia Yip , Jonathan Fawcett , Mark Donoghoe , Kate Walker , Matthew E. Burge , Sivakumar Gananadha , Marion Harris , Morteza Aghmesheh , Warren Lance Joubert , Val Gebski , John Simes , David Goldstein
Ann Surg Oncol. 2020 Jul;27(7):2506-2515

Single institution retrospective review of perioperative chemotherapy in adult and adolescent patients with operable osteosarcoma
Aaron R Hansen Brett GM Hughes Sanjoy Paul Peter Steadman Scott Sommerville Ian C Dickinson Euan T Walpole Damien B Thomson Helen G Mar Fan Warren L Joubert
Asia Pac J Clin Oncol. 2016 Jun;12(2):e222-8

ICECREAM: randomised phase II study of cetuximab alone or in combination with irinotecan in patients with metastatic colorectal cancer with either KRAS, NRAS, BRAF and PI3KCA wild type, or G13D mutated tumours
Eva Segelov, Paul Waring, Jayesh Desai, Kate Wilson, Val Gebski,Subotheni Thavaneswaran, Elena Elez, Craig Underhill, Nick Pavlakis, Lorraine Chantrill, Louise Nott, Michael Jefford, Mustafa Khasraw, Fiona Day, Harpreet Wasan, Fortunato Ciardiello, Chris Karapetis, Warren Joubert, Guy van Hazel, Andrew Haydon, Tim Price, Sabine Tejpar, Niall Tebbutt and Jeremy Shapiro

BMC Cancer201616:339
Patterns of care for patients with advanced soft tissue sarcoma: experience from Australian sarcoma services
Susie Bae, Philip Crowe, Raghu Gowda, Warren Joubert, Richard Carey-Smith, Paul Stalley and Jayesh Desai Clinical Sarcoma Research20166:11

Initial survival outcomes for the AGITG GAP study – a phase II study of perioperative nab-paclitaxel and gemcitabine for resectable pancreatic ductal adenocarcinoma (PDAC).
Andrew Barbour, Nicholas O’Rourke, Howard Chan, Yu Jo Chua, James Kench, Rodney J Hicks, Jaswinder S. Samra, Nick Pavlakis, Koroush S Haghighi, Sonia Yip, Mark Donoghoe, Cheryl Friend, Matthew E. Burge, Jonathan Fawcett, Marion Harris, Morteza Aghmesheh, Warren Lance Joubert, , John Simes, David Goldstein
Ann Surg Oncol 2020 Jul;27(7):2506-2515

ICE CREAM: Irinotecan cetuximab evaluation and the cetuximab response evaluation among patients with G13D mutation.
Eva Segelov , Kate Wilson , Val Gebski , Paul Michael Waring , Josep Tabernero , Harpreet Wasan , Fortunato Ciardiello , Jayesh Desai , Craig Underhill , Christos Stelios Karapetis , Mustafa Khasraw , Louise M. Nott , Warren Lance Joubert , Nick Pavlakis , Guy Van Hazel , Lorraine A. Chantrill , Timothy Jay Price , Michael Jefford , Andrew Mark Haydon , Jeremy David Shapiro

J Clin Oncol 2016 Jul 1;34(19):2258-64
Neoadjuvant chemotherapy or chemoradiotherapy for adenocarcinoma of the esophagus

Els Visser MD David Edholm MD, PhD B. Mark Smithers MBBS, FRACS, FRCSEng, FRCSEd
Iain G. Thomson MBBS, FRACS Bryan H. Burmeister Euan T. Walpole David C. Gotley FRACS, MD, PhD Warren L. Joubert Victoria Atkinson Tao Mai Janine M. Thomas BsHSc Andrew P. Barbour MBBS, PhD, FRACS, FACS
J Surg Oncol. 2018 Jun;117(8):1687-1696

Catheter-Related Thrombosis Incidence and Risk Factors in Adult Cancer Patients with Central Venous Access Devices
Marc Ellis, Satomi Okano, Andrew McCann, Angela McDowall, Rosita Van Kuilenburg, Alexandra McCarthy, Warren Joubert, John Harper, Mark Jones and Peter Mollee
Blood 2017 130:2096;

Analysis of plasma biomarkers potentially associated with antiangiogenic resistance in NCIC CTG/AGITG CO.20: A phase III randomized trial of cetuximab (CET) plus either brivanib alaninate (BRIV) or placebo in patients (pts) with chemotherapy refractory, k-RAS wild-type (WT), metastatic colorectal carcinoma (mCRC).
Jeremy David Shapiro , Lillian L. Siu , Christopher J O’Callaghan , John Raymond Zalcberg , Malcolm J. Moore , Timothy Jay Price , Catherine Doyle , John Simes , Brian Peter Findlay , Michelle F. Cronk , Asif Shaikh ,
Warren Lance Joubert , Benoit Samson , Antonino Bonaventura , Craig Underhill , David Wyld , Ian B. Walters , Penny Phillips , Dongsheng Tu , Derek J. Jonker ,

Catheter-Associated Bloodstream Infection Incidence and Risk Factors in Adults with Cancer: A Prospective Cohort Study.
Peter Mollee, Mark Jones, Jenny Stackelroth, Rosita van Kuilenburg, Warren Joubert, Joan Faoagali, David Looke, John Harper and Archie Clements
Blood 2009 114:1382;

Catheter-Associated Bloodstream Infections (CA-BSI) in Adults with Cancer: A Prospective Randomized Controlled Trial
Peter Mollee, Satomi Okano, David Looke, Glen Kennedy, John Harper, John Clouston, Rosita Van Kuilenburg, Alanna Geary, Warren Joubert, Melissa Eastgate and Mark Jones
Blood 2017 130:4729;

CIC-rearranged sarcoma of the pleura: an unreported primary site, expanding the anatomical distribution of an emerging entity
Lisa Wilkinson John Coucher Michelle Murphy Warren Joubert Caroline Cooper Pathology 2018 Jun;50(4):469-472

A single centre audit on the pattern of care of patients with well differentiated Neuroendocrine Tumours compared to current guidelines: 372
Lee, Shu; Joubert, Warren;
Asia-pacific Journal of Clinical Oncology, volume 11 2015

Catheter-associated bloodstream infection incidence and risk factors in adults with cancer: a prospective cohort study
Mollee, P; Jones, M; Stackelroth, Jenny; Van Kuilenburg, R; Joubert, W; Faoagali, J; Looke, D; Harper, J; Clements, Archie;
Journal of Hospital Infection, volume 78 2011

Activity of cediranib in alveolar soft part sarcoma (ASPS) confirmed by CASPS (cediranib in ASPS), an international, randomised phase II trial (C2130/A12118).
Judson, Ian Robert; Morden, James P; Leahy, Michael Gordon; Bhadri, Vivek; Campbell-Hewson, Quentin; Cubedo, Ricardo; Dangoor, Adam; Hennig, Ivo M; Joubert, Warren Lance; Kernaghan, Sarah;
American Society of Clinical Oncology 2017

Single Institution experience of hyperthermic intraperitoneal chemotherapy (HIPEC) Xu, W; Sparks, D; Atkinson, V; Lutton, N; Joubert, W; Meade, B;
Asia-pacific Journal of Clinical Oncology, volume 9 2013

Cediranib in patients with alveolar soft-part sarcoma (CASPS): a double-blind, placebo-controlled, randomised, phase 2 trial
Judson, Ian; Morden, James P; Kilburn, Lucy; Leahy, Michael; Benson, Charlotte; Bhadri, Vivek; Campbell-Hewson, Quentin; Cubedo, Ricardo; Dangoor, Adam; Fox, Lisa;
The Lancet Oncology, volume 20 2019

FA03. 05: Neoadjuvant chemotherapy or chemoradiotherapy for adenocarcinoma of the esophagus
Visser, Els; Edholm, David; Smithers, Mark; Thomson, Iain; Burmeister, Bryan; Walpole, Euan; Gotley, David; Joubert, Warren; Atkinson, Victoria; Mai, Tao;
Diseases of the Esophagus, volume 31 2018

Single institution experience of Hyperthermic Intraperitoneal Chemotherapy
Xu, Wen; Sparks, David; Atkinson, Victoria; Joubert, Warren; Lutton, Nicholas; Meade, Brian; 2013

Single institution experience of Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for management of peritoneal malignancies
Xu, Wen; Sparks, David; Atkinson, Victoria; Lutton, Nicholas; Joubert, Warren; Meade, Brian;

The AGITG ICECREAM STUDY: The Irinotecan Cetuximab Evaluation and Cetuximab Response Evaluation Amongst Patients with a G13D Mutation-analysis of outcomes in patients with “Quad WT”.
Segelov, Eva; Shapiro, Jeremy; Thavaneswaran, Subotheni; Waring, Paul; Desai, Jayesh; Mann, Kirsty; Elez, Maria Elena; Chantrill, Lorraine A; Pavlakis, Nick; Nott, Louise;
J Clin Oncol 35 (15) 3572.

Neoadjuvant chemotherapy or chemoradiotherapy for adenocarcinoma of the esophagus
Smithers, B Mark; Thomson, Iain G; Burmeister, Bryan H; Joubert, Warren L; Atkinson, Victoria; Mai, Tao; BsHSc, Janine M Thomas; Barbour, Andrew P;
J Surg Oncol. 2018 Jun;117(8):1687-1696